The Bay Town Trolley provides public bus transportation. The trolley route includes major shopping centers, hospitals and transportation to Panama City Beach. Southern Greyhound provides intercity bus transportation. Small package express service is available through Airborne Express, Federal Express, Purolator and UPS, which maintain terminals in the Panama City area.

Commercial airline service at the Panama City / Bay County International Airport is provided by Northwest Airlink to Memphis, USAir Express to Tampa / Orlando and Atlantic Southeast Airlines, which provides jet service to Atlanta.

The following car rental agencies are located either at the Airport or in convenient locations near the Airport: AAA, Alamo, Avis Budget, Cartempts USA, Dollar Enterprise, Hertz, National, Sears and U-Save. Several taxi and limousine services offer ground transportation from the Airport.

The Bay Line Railroad provides rail freight service to Panama City businesses and industry and to Port Panama City. "The Bay Line" interconnects with both the CSX Transportation Company in Dothan, Alabama and in Cottondale, Florida. "The Bay Line" also interconnects with the Norfolk Southern Railroad in Dothan, Alabama.